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Aqua Man said:
Will be harvesting most today.

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So jealous. been on the fence about getting a run going again. going to do a box just like this, worked perfect for me last time. something about the fresh ones that makes them like some delicacy, it's different.
i used to love how just "potency sampling" one or two small fresh ones would usually put me a little out there but in the warmest of ways, lol
sound like i'm trippin now, my mind is so there

looks good aqua! like you say, a little tall, but still very good, put me down nostalgia lane there for a minute
 
Psilocybin delays aging, extends lifespan, new Emory study suggests
Lara Moore @ Emory University

As revenues from the anti-aging market — riddled with hope and thousands of supplements — surged past $500 million last year, Emory University researchers identified a compound that actively delays aging in cells and organisms.

A newly published study in Nature Partner Journals’ Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, extended the cellular lifespan of human skin and lung cells by more than 50%.

In parallel, researchers also conducted the first long-term in vivo study evaluating the systemic effects of psilocybin in aged mice of 19 months, or the equivalent of 60–65 human years. Results indicated that the mice that received an initial low dose of psilocybin of 5 mg/kg, followed by a monthly high dose of 15 mg/kg for 10 months, had a 30% increase in survival compared to mice who hadn’t received any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth.

While traditionally researched for its mental health benefits, this study suggests that psilocybin impacts multiple hallmarks of aging by reducing oxidative stress, improving DNA repair responses, and preserving telomere length. Telomeres are the structured ends of a chromosome, protecting it from damage that could lead to the formation of age-related diseases, such as cancer, neurodegeneration or cardiovascular disease. These foundational processes influence human aging and the onset of these chronic diseases.

The study concludes that psilocybin may have the potential to revolutionize anti-aging therapies and could be an impactful intervention in an aging population.
“Most cells in the body express serotonin receptors, and this study opens a new frontier for how psilocybin could influence systemic aging processes, particularly when administered later in life,” says Louise Hecker, PhD, senior author on the study, and former associate professor at Emory, where the research was initiated and funded.

While much of what researchers know about psilocybin relates to the brain, few studies have examined its systemic impacts. Many people associate psilocybin with the hallucinogenic impacts, but the majority of the cells in the body express serotonin receptors.

“Our study opens new questions about what long-term treatments can do. Additionally, even when the intervention is initiated late in life in mice, it still leads to improved survival, which is clinically relevant in healthy aging,” adds Hecker, currently an associate professor at Baylor College of Medicine.


Not just a longer life, but a healthier life

This news comes on the heels of KFF’s recent report that U.S. life expectancy is still below that of other countries similar in income and size, with an average lifespan of 78.4 years, compared to 82.5 years elsewhere. Not only was it the lowest, but as the lifespan in similar countries increased by 7.9 years from 1980-2022, the U.S. life expectancy has only increased by 4.7 years.

“This study provides strong preclinical evidence that psilocybin may contribute to healthier aging — not just a longer lifespan, but a better quality of life in later years,” says Ali John Zarrabi, MD, director of psychedelic research at Emory's Department of Psychiatry. “As a palliative care physician-scientist, one of my biggest concerns is prolonging life at the cost of dignity and function. But these mice weren’t just surviving longer — they experienced better aging,” adds Zarrabi, co-investigator of the study.

Zarrabi emphasizes the importance of further research in older adults, as well as the well-documented overlap between physical and mental health.

“Emory is actively involved in Phase II and III clinical trials of psilocybin-assisted therapy for depression, and these results suggest we also need to understand psilocybin’s systemic effects in aging populations,” says Zarrabi. “My hope is also that if psilocybin-assisted therapy is approved as an intervention for depression by the FDA in 2027, then having a better quality of life would also translate into a longer, healthier life.”
 
Observer said:
Psilocybin delays aging, extends lifespan, new Emory study suggests
Lara Moore @ Emory University

As revenues from the anti-aging market — riddled with hope and thousands of supplements — surged past $500 million last year, Emory University researchers identified a compound that actively delays aging in cells and organisms.

A newly published study in Nature Partner Journals’ Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, extended the cellular lifespan of human skin and lung cells by more than 50%.

In parallel, researchers also conducted the first long-term in vivo study evaluating the systemic effects of psilocybin in aged mice of 19 months, or the equivalent of 60–65 human years. Results indicated that the mice that received an initial low dose of psilocybin of 5 mg/kg, followed by a monthly high dose of 15 mg/kg for 10 months, had a 30% increase in survival compared to mice who hadn’t received any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth.

While traditionally researched for its mental health benefits, this study suggests that psilocybin impacts multiple hallmarks of aging by reducing oxidative stress, improving DNA repair responses, and preserving telomere length. Telomeres are the structured ends of a chromosome, protecting it from damage that could lead to the formation of age-related diseases, such as cancer, neurodegeneration or cardiovascular disease. These foundational processes influence human aging and the onset of these chronic diseases.

The study concludes that psilocybin may have the potential to revolutionize anti-aging therapies and could be an impactful intervention in an aging population.
“Most cells in the body express serotonin receptors, and this study opens a new frontier for how psilocybin could influence systemic aging processes, particularly when administered later in life,” says Louise Hecker, PhD, senior author on the study, and former associate professor at Emory, where the research was initiated and funded.

While much of what researchers know about psilocybin relates to the brain, few studies have examined its systemic impacts. Many people associate psilocybin with the hallucinogenic impacts, but the majority of the cells in the body express serotonin receptors.

“Our study opens new questions about what long-term treatments can do. Additionally, even when the intervention is initiated late in life in mice, it still leads to improved survival, which is clinically relevant in healthy aging,” adds Hecker, currently an associate professor at Baylor College of Medicine.


Not just a longer life, but a healthier life

This news comes on the heels of KFF’s recent report that U.S. life expectancy is still below that of other countries similar in income and size, with an average lifespan of 78.4 years, compared to 82.5 years elsewhere. Not only was it the lowest, but as the lifespan in similar countries increased by 7.9 years from 1980-2022, the U.S. life expectancy has only increased by 4.7 years.

“This study provides strong preclinical evidence that psilocybin may contribute to healthier aging — not just a longer lifespan, but a better quality of life in later years,” says Ali John Zarrabi, MD, director of psychedelic research at Emory's Department of Psychiatry. “As a palliative care physician-scientist, one of my biggest concerns is prolonging life at the cost of dignity and function. But these mice weren’t just surviving longer — they experienced better aging,” adds Zarrabi, co-investigator of the study.

Zarrabi emphasizes the importance of further research in older adults, as well as the well-documented overlap between physical and mental health.

“Emory is actively involved in Phase II and III clinical trials of psilocybin-assisted therapy for depression, and these results suggest we also need to understand psilocybin’s systemic effects in aging populations,” says Zarrabi. “My hope is also that if psilocybin-assisted therapy is approved as an intervention for depression by the FDA in 2027, then having a better quality of life would also translate into a longer, healthier life.”
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"Nature" has provided the "information", we just need/have to Decode It.
 
Bioaccumulated said:
How do you guys feel about sonoran spores for purchases? I havent run tek in a long long time. Used to harvest local panoleus subblatteus and make teas but i really enjoy P envy....golden regs.....micro dose though i cant handle anymore ceiling hangs lmaop
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I'm not sure if this is what you're asking but I've only heard good things from Ground Zero Mycos Lab. He's got a website and an app and a pretty big following on Reddit.
 
Can folks walk me thru the latest way of doing tubs? Substrates? I saw a cat at work who uses uncle bens packs!!!!!!! Would like to start micros as soon as possible......thankyou for your candor.
 
We switched from jars to bags .we can buy the liquid culture syringes here ,they work way faster than spore syringes. I also made an incubator to speed up colonization. It's just two totes inside each other the bottom one filled with water and has a aquarium heater in it. I set that at 80.spawn bags go in top dry tote. I buy the pre sterilized grain bags,but they aren't hard to make. The video here is almost exactly how we do it.we just do our sterile work inside a glove box dont have a flow hood. Only have to grow them every couple years we dont eat that many.its 10 times easier than growing weed.just gota be clean at the start.
 
stonemason said:
We switched from jars to bags .we can buy the liquid culture syringes here ,they work way faster than spore syringes. I also made an incubator to speed up colonization. It's just two totes inside each other the bottom one filled with water and has a aquarium heater in it. I set that at 80.spawn bags go in top dry tote. I buy the pre sterilized grain bags,but they aren't hard to make. The video here is almost exactly how we do it.we just do our sterile work inside a glove box dont have a flow hood. Only have to grow them every couple years we dont eat that many.its 10 times easier than growing weed.just gota be clean at the start.
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i've done it very similar.. and old cooler with a thermostat and heat lamp inside. i made a fruiting chamber with a tote water and aquarium heater, that was when i used brf jars..

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did the mono tubs four times.. started twice with jars and spore syringes.. then did twice myself with cultures and bags.

i still have some left yet... still have all the gear too.. haven't done it in a while.. in fact my last colonization chamber is now my knockoff cannatrol. that old wine fridge has worn many hats over the years!! hehehe

i grew a few legal edible mushrooms since then but they don't count!! haha we really like the lions mane, taste just like crab meat!!! they've all been in bags and bought syringe. i make the mix with wood pellets and pressure cool em myself but the spores are purchased. and i stopped using a glove box a long time ago.. i just Ozone and UV a small bathroom first with all the gear inside and slip in afterwards and inoculate right in the open, get to use the counters, the light.. makes it pretty easy. i mean come on that bathroom gets bleached all the time.. it's cleaner than my old glovebox in there!! haha

i'm like Bioaccumulated though, i only micro anymore.. my last heavy trip was for a primus concert philly quite a few years back now..
 
Stoneyluv said:
i've done it very similar.. and old cooler with a thermostat and heat lamp inside. i made a fruiting chamber with a tote water and aquarium heater, that was when i used brf jars..

View attachment 122356

did the mono tubs four times.. started twice with jars and spore syringes.. then did twice myself with cultures and bags.

i still have some left yet... still have all the gear too.. haven't done it in a while.. in fact my last colonization chamber is now my knockoff cannatrol. that old wine fridge has worn many hats over the years!! hehehe

i grew a few legal edible mushrooms since then but they don't count!! haha we really like the lions mane, taste just like crab meat!!! they've all been in bags and bought syringe. i make the mix with wood pellets and pressure cool em myself but the spores are purchased. and i stopped using a glove box a long time ago.. i just Ozone and UV a small bathroom first with all the gear inside and slip in afterwards and inoculate right in the open, get to use the counters, the light.. makes it pretty easy. i mean come on that bathroom gets bleached all the time.. it's cleaner than my old glovebox in there!! haha

i'm like Bioaccumulated though, i only micro anymore.. my last heavy trip was for a primus concert philly quite a few years back now..
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I did four bags of the gold teachers this fall and mixed 2 of them in the mulch of my garden path.hoping I can get a perennial patch going for spring out side. The lions manes are good.we have a huge patch that grow on a dead maple in the woods every fall.
 
stonemason said:
I did four bags of the gold teachers this fall and mixed 2 of them in the mulch of my garden path.hoping I can get a perennial patch going for spring out side. The lions manes are good.we have a huge patch that grow on a dead maple in the woods every fall.
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i've dumped all my old cubes outside in the same spot each time hoping for some wild fruits.. i never put effort in it like that though, be awesome to poke around in the spring time and see if any mycelium is growing!! GT has always been one of my favorites.. to grow and eat.

been wanting to buy some of those shitake plugs and make a little log home out back.
 
Stoneyluv said:
i've dumped all my old cubes outside in the same spot each time hoping for some wild fruits.. i never put effort in it like that though, be awesome to poke around in the spring time and see if any mycelium is growing!! GT has always been one of my favorites.. to grow and eat.

been wanting to buy some of those shitake plugs and make a little log home out back.
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I covered the paths in straw .sprayed it 3 or 4 times with my knf nuitrients before it got cold.we will see. There might be to many fungal networks already out there, im not sure how well they will compete. Got oysters to come up that way.I didn't need all the bags. 2 monotubes was way more than enough to hold us over didn't want to throw the other 2 bags away. Ya the logs cultures would be super cool. I always realy enjoyed mushroom cultivation, just never made it a real serious commitment. Tried to get some perennial moral spots going in our woods with no luck a few years back.they quit growing back there after all the ash trees died. Hunting wild mushrooms is one of my favorite things to do.we had a drought this year so the fall flushes didn't realy happen.most years we find hens of the woods ,chicken of the woods,lions manes,puff balls,and all kinds of boletes.one of these years im gona go out west and pick one of the big wild fires for burn morels.
 
Its interesting to me that the sterilization process indoors when done by hand needs to be done with epic attention being paid to being 100% sterile. while outdoors under leaf litter et6c its happening in substrates not necc gone through a sterilization process we would immediately recognize. For me its about the mycellium underneath and the way they communicate. I recently found ghost pipe on a deer run by railroad tracks and that made me smile.
 
Ya its crazy in the wild the mushrooms thrive because of thier symbiotic relationships with the trees and plants and bacteria,rather than sterilization. Alot of them won't fruit until the the host tree or plant dies.we see this alot with morel hunting.the ones that live with the elms won't fruit until the elm dies, and gradually stop fruiting the older the dead tree gets.but the pernial patches that lived with the live ash trees came up every year until the ash trees died then they stopped .almost opposite growth patterns same mushrooms different host trees.they want live ash trees to fruit but dead elms and apples.

Those ghost pipes are cool.i found a huge patch a few years back.i didn't realize they are actualy a plant not a mushroom. I made a alchol tintiture from some.its supposed to be a good pain killer.it turns out bright purple.it is also supposed to give you wild dreams if you take to much...
 
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